Gentamicin is an aminoglycoside antibiotic . It is bactericidal, has a dose-dependent killing curve, remains stable when exposed to heat and is soluble in water. These four characteristics make it especially suited for use in bone cement.
Gentamicin loaded bone cement
Gentamicin is mixed in bone cement for prophylaxis against infections after arthroplasties. The substance is slowly eluted in the surrounding tissue.
Numerous studies have investigated the rate and duration of antibiotic release from bone cement 6 and gentamicin exhibits the best release.7 Leaching out, a characteristic shared by all antibiotics, is especially prevalent with gentamicin.